A Model System of Error Commission, Detection and Correction for High Precision Error Coupling in the Error Monitoring and Processing System: Role of Glycemic Allostasis Regulation

Abstract

Error commission, detection, and correction are the products of the activities of a complex neural network referred to the error monitoring and processing system (EMPS) diffusely located in different brain regions. High-precision error coupling is the hallmark of EMPS functioning that is the result of effective neural processing and monitoring of error signals. Error commission, detection and correction as generic entities of the neural network of EMPS are influenced by some factors classified under two broad categories: endogenous and endogenous. We had previously reported the effect of exogenous and endogenous alcohol as well as other factors that may affect this system. It is imperative to note that cells regulating the activities of the brain (including regions responsible for EMPS) rely mainly on the metabolic substrate "glucose" to ensure adequate functioning. More importantly, it is not just the availability of glucose that ensures adequate functioning of neurons, but the process by which glycemia stabilization is achieved through the balancing of glucose consumption rate and release into the blood stream under a variety of physiological stressors (cognitive or mental workload e.g. mental work executed by participants in an experimental conditions over a period 4-6 hours on fasting) to maintain the "set point". This process that is referred to glycemic allostasis involves the utilization of glucose molecules to maintain the anatomo-physiological integrity of cells comprising the neural network of EMPS. Unfortunately, little attention has been given to the allostatic regulation of glycemia that is necessary to ensure adequate functioning and provide high precision error coupling in the EMPS. In this paper, we produced a model system of error commission, detection, and correction and examine the possible effects and mechanisms of glycemic allostasis regulation on error coupling in the EMPS.