Accumulation of radioactivity in the pancreas after intravenous administration of [13N]ammonia

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology Pub Date : 1992-07-01 DOI:10.1016/0883-2897(92)90148-R

Hideo Saji , Yuji Kuge , Kazutaka Yamamoto , Yasuhiro Magata , Yoshiharu Yonekura , Junji Konishi , Akira Yokoyama

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引用次数: 1

Abstract

A biodistribution study of [¹³N]ammonia in rats showed a high accumulation of radioactivity in the pancreas soon after the intravenous injection of this tracer. In humans, the pancreas was also clearly visualized by dynamic positron emission tomography soon after the intravenous injection of [¹³N]ammonia. To investigate the mechanism of the pancreatic accumulation of [¹³N]ammonia, in vitro studies with pancreatic slices and in vivo biodistribution and metabolism studies were carried out in rats. The results indicated that [¹³N]ammonia enters the pancreas from the blood by diffusion at a rate dependent on local blood flow, and then is rapidly incorporated into the amino acid fraction (mainly the glutamine fraction), followed by its incorporation into protein. These findings suggest that [¹³N]ammonia could be useful for diagnostic imaging of the pancreas.

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静脉注射[13N]氨后胰腺放射性积累

[13N]氨在大鼠体内的生物分布研究表明，在静脉注射这种示踪剂后不久，胰腺中的放射性积累很高。在人体中，静脉注射[13N]氨后不久，动态正电子发射断层扫描也清晰地显示了胰腺。为了探讨[13N]氨在胰腺蓄积的机制，我们采用胰腺切片进行了体外研究，并在大鼠体内进行了生物分布和代谢研究。结果表明，[13N]氨通过扩散从血液进入胰腺，其扩散速率取决于局部血流量，然后迅速并入氨基酸部分(主要是谷氨酰胺部分)，随后并入蛋白质。这些发现表明[13N]氨可能对胰腺的诊断成像有用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

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