Use of Cystatin C in the Early Diagnosis of Contrast-Induced Nephropathy.

Abstract

Objective The aim of this study was to explore the application values of Cystatin C (cys-C) in the early diagnosis of contrast-induced nephropathy (CIN). Methods Three hundred patients who performed the percutaneous coronary intervention (PCI) with non-ionotropic or iso-osmotic contrast agent, were selected. The levels of Cys C and serum creatinine (Scr) at the 4 time points: before PCI, 24, 48 and 72 hours after PCI were detected. Acording to the occurrence of CIN within 72 hours of opacification, the patients were divided into the CIN group and non-CIN group, and the changes of Cys C and Scr at different time points between the two groups were compared and the Roc curve was used to compare the early diagnostic values of the two indicators towards CIN. Results Among the 300 patients, 35 cases related to CIN, with the incidence rate at 11.67%. The postoperative 24 h Cys C level of the CIN group significantly increased more than the non-CIN group, while the Scr level increased at the postoperative 48 hour. The area under the ROC curve of postoperative 24 hour Cys C was bigger than that of Scr (0.898 vs 0.885, p = 0.001). The sensitivity of cys-C as the CIN diagnostic standard was 85.7%, with the specificity at 82.4%. Conclusions The post-opacification 24 hour serum Cys C concentration exhibited certain significance towards the early diagnosis of CIN, and worthy of clinical generalization.