Identification of the possible negative impact of the drilling reagent brucit on workers involved in the construction of wells

Abstract

In the technological processes of the construction of oil and gas wells, a variety of general-purpose inorganic chemicals are used. The ingress of these reagents into the body of drilling workers together with inhaled air, food intake, through the pores and mucous membrane is currently not sufficiently studied. The work investigated the effect of the drilling reagent brucit on the lung tissue of rats. During inhalation administration of brucite to rats, dystrophic processes were noted in their lungs, which were accompanied by the development of chronic inflammation, acute macrophage reaction. Morphometric analysis also showed a significant decrease in the area of the alveolar space and the area of the bronchus of medium caliber. In the lungs, the formation of many airless areas alternating with emphysematous-altered, the severity of which increased with the duration of exposure to the drilling reagent.           Scientific novelty: In the work, the early unexplored effect of the drilling reagent brucit on the lung tissue of rats was determined. The categories of workers exposed to brucite at all stages of production are determined.For the first time, morphological features of the lungs in rats were determined against the background of inhaled administration of brucite particles. Based on the results of the study, the toxicological characteristics of the drilling reagent brucit are given. Research results:Brucite particles present in the air, when inhaled, passed through the nose, trachea, bronchi and reached the alveoli of non-linearalbinorats rats. Obviously, part of the administered dose was excreted by the body with excrement and mucus, and the other part was absorbed and then distributed to organs and tissues. A control section of a medium-caliber bronchus is shown in Figure 2. 14 days after the introduction of brucite particles, changes in lung tissue can be seen on microphotographs of the histological section. Focal fullness of the capillaries of the interalveolar septa is revealed. The changes registered on the 14th day after the introduction of brucite particles are shown in Figure 3.