Assessing Mild Cognitive Impairment Using Portable Electroencephalography: The P300 Component

Hannah Smith
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引用次数: 1

Abstract

Increased prevalence of mild cognitive impairments (MCIs) and dementias are a growing concern as the population ages, which produces a need for an objective, accessible, and cost-effective tool to facilitate early detection and intervention. This article investigates whether a portable electroencephalography (EEG) system can provide an effective measure of MCI using a visual oddball task to target the memory and attention event-related potential (ERP) component called the P300. In this study, 40 participants were separated into two groups: individuals with a diagnosed cognitive impairment and a healthy age-matched control group. Participants completed two typical pen-and-paper MCI assessments to gather behavioural data, which were followed by a perceptual EEG oddball task to gather brain data. Results show that the MCI group demonstrated decreased behavioural task performance in the pen-and-paper assessments and a modulated brain response during the oddball task when compared to healthy controls, which the portable EEG system revealed to be a decreased P300 peak amplitude. These results indicate the capability of portable EEGs to identify biomarkers for MCI and their potential use in the diagnostic process. This capability could provide major benefits to patients, their families, and physicians, and would also assist with Alzheimer’s research. Future research could expand on these findings by applying a lifespan or disease-span approach to investigate P300 changes in the course of a healthy individual’s life compared to P300 changes in individuals with MCI over the entire course of their disease. This research could also cultivate a greater understanding of how MCI progresses, which could improve diagnostic or treatment development.
使用便携式脑电图评估轻度认知障碍:P300成分
随着人口老龄化,轻度认知障碍(MCIs)和痴呆症的患病率日益增加,这就需要一种客观、可获得且具有成本效益的工具来促进早期发现和干预。本文研究了便携式脑电图(EEG)系统是否可以提供一种有效的MCI测量方法,该方法使用视觉奇球任务来针对记忆和注意事件相关电位(ERP)组成部分P300。在这项研究中,40名参与者被分为两组:诊断为认知障碍的个体和年龄匹配的健康对照组。参与者完成了两项典型的纸笔MCI评估,以收集行为数据,随后是一项感知脑电图古怪任务,以收集大脑数据。结果表明,与健康对照组相比,MCI组在笔和纸的行为任务评估中表现出下降的表现,并且在古怪任务中大脑反应有所调节,便携式脑电图系统显示P300峰值幅度下降。这些结果表明便携式脑电图识别MCI生物标志物的能力及其在诊断过程中的潜在应用。这种能力可以给病人、他们的家人和医生带来很大的好处,也可以帮助阿尔茨海默病的研究。未来的研究可以通过应用寿命或疾病跨度方法来研究健康个体生命过程中P300的变化,并将其与MCI个体在整个疾病过程中的P300变化进行比较,从而扩展这些发现。这项研究还可以加深对轻度认知障碍如何发展的理解,从而改善诊断或治疗的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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