Hugo Girão, Naoyuki Okada, T. Rodrigues, Alexandra Silva, A. C. Figueiredo, Z. García, Tatiana Moutinho‐Santos, I. Hayashi, Jorge E Azevedo, Sandra Macedo-Ribeiro, H. Maiato
{"title":"CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments","authors":"Hugo Girão, Naoyuki Okada, T. Rodrigues, Alexandra Silva, A. C. Figueiredo, Z. García, Tatiana Moutinho‐Santos, I. Hayashi, Jorge E Azevedo, Sandra Macedo-Ribeiro, H. Maiato","doi":"10.1083/jcb.201905080","DOIUrl":null,"url":null,"abstract":"Girão et al. use structure-guided functional mutants of CLASP2 to show that recognition of growing microtubule plus-ends through EB–protein interaction and the ability to associate with curved microtubule protofilaments through TOG2 and TOG3 domains promote growth and stabilization of kinetochore–microtubules required for poleward flux.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"23","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1083/jcb.201905080","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 23
Abstract
Girão et al. use structure-guided functional mutants of CLASP2 to show that recognition of growing microtubule plus-ends through EB–protein interaction and the ability to associate with curved microtubule protofilaments through TOG2 and TOG3 domains promote growth and stabilization of kinetochore–microtubules required for poleward flux.