Preliminary studies of reactions using colominic and sialic acids as prototypes to bivalent vaccine against S. agalactiae and A. baumannii

Abstract

Introduction: Bioconjugation reactions play an important role in developing molecular arrangement of some different chemical species in new assembled structures. Such structures are of great importance in the vaccinology field against important pathogens. The pathogen S. agalactiae appears as a threat of invasive infection in neonates, characterizing a common problem to several countries. Similarly, the bacterium A. baumannii has been a problem in Brazilian hospitals, mainly due to the increasing development of resistance to different antimicrobial drugs. Therefore, a use of conjugate bivalent vaccines rises as an answer to prevention of nosocomial infections caused by this kind of pathogens. Hence, the development of new chemical approaches for synthesis of bivalent vaccines is imperative. A primary step for development of new methodologies about oxidation using prototypes that mimic functional groups present in S. agalactiae matrix was realized.