Langerhans cells in the lymph node: mirror section and immunoelectron microscopic studies.

M Shamoto, M Shinzato, S Hosokawa, C Kaneko, T Hakuno, K Nomoto
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引用次数: 16

Abstract

Cells immunostained with antibodies against both OKT-6 and S-100 protein were observed only in superficial and hilar lymph nodes draining tissues with predominantly squamous epithelia. In contrast, in mesenteric lymph nodes and the spleen, only S-100 protein-positive, but OKT-6-negative cells were found. We suspect that the S-100 and OKT-6-positive cells might be Langerhans cells (LC) and the S-100-positive, OKT-6-negative cells, interdigitating reticulum cells (IDC). We further postulate that the LC in superficial and hilar lymph nodes might migrate from squamous epithelia, with which contact is required for the formation of Birbeck granules.

淋巴结中的朗格汉斯细胞:镜像切片和免疫电镜研究。
用OKT-6和S-100蛋白抗体免疫染色的细胞仅在以鳞状上皮为主的浅表和淋巴结排液组织中观察到。而在肠系膜淋巴结和脾脏中,只有S-100蛋白阳性,而okt -6阴性。我们怀疑S-100和okt -6阳性的细胞可能是朗格汉斯细胞(LC),而S-100阳性、okt -6阴性的细胞可能是交错网状细胞(IDC)。我们进一步假设,浅层淋巴结和淋巴结门部淋巴结中的LC可能从鳞状上皮迁移而来,与鳞状上皮接触是形成Birbeck颗粒所必需的。
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