Evaluation of sympathetic nervous system function in normal and spontaneously hypertensive rat hearts with dynamic SPECT imaging

2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC) Pub Date : 2013-10-01 DOI:10.1109/NSSMIC.2013.6829043

Yunlong Zan, R. Boutchko, Qiu Huang, G. Gullberg

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Abstract

123I-MIBG is an analogue of the norepinephrine uptake in the presynaptic portion of the sympathetic neurons that innervate the heart. The abnormal metabolism of 123I-MIBG is used to diagnose potential heart failure. This paper quantitatively compares the metabolism of 123I-MIBG in SHRs and Wistar-Kyoto normal rats. Dynamic projection data were acquired for 100 min in 1-sec time frames with an angular step of 2 degrees per frame on a dual-head GE Millennium VG Hawkeye SPECT/CT scanner equipped with custom pinhole collimators. The time activity curves of radiotracer in blood pool and myocardium were extracted from the projections through the spatiotemporal dimension reduction method developed previously for dynamic cardiac SPECT reconstruction. The kinetic parameters were estimated by fitting the estimate time activity curves to a compartmental model. The distribution volumes (DVs) of the radiotracer in the myocardium were calculated. The DV of SHRs was greater (p=2.4E-4) than that of WKY normal rats, indicating the development of cardiac hypertrophy in the SHRs.

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动态SPECT评价正常和自发性高血压大鼠心脏交感神经系统功能

123I-MIBG是支配心脏的交感神经元突触前部分去甲肾上腺素摄取的类似物。123I-MIBG代谢异常可用于诊断潜在心力衰竭。本文定量比较了SHRs和Wistar-Kyoto正常大鼠123I-MIBG的代谢。在配备定制针孔准直器的GE Millennium VG Hawkeye双头SPECT/CT扫描仪上，以每帧2度的角度步长，以1秒的时间帧获取100分钟的动态投影数据。利用动态心肌SPECT重建的时空降维方法，从投影中提取血池和心肌中放射性示踪剂的时间活度曲线。通过将估计时间活度曲线拟合到室室模型中来估计动力学参数。计算示踪剂在心肌中的分布体积(DVs)。与WKY正常大鼠相比，SHRs的DV显著增加(p=2.4E-4)，提示SHRs发生心肌肥厚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)

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