The effects of ovomacroglobulin on gingival wound healing in rats.

Periodontal clinical investigations : official publication of the Northeastern Society of Periodontists Pub Date : 1992-01-01

Y Ofuji, T Suzuki, H Yoshie, K Hara, M Adachi

{"title":"The effects of ovomacroglobulin on gingival wound healing in rats.","authors":"Y Ofuji, T Suzuki, H Yoshie, K Hara, M Adachi","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effects of ovomacroglobulin (OMG), an alpha 2-macroglobulin-like protease inhibitor, were tested on periodontal surgical would healing in 60 Wistar rats. The animals were divided into two groups, one receiving topical application of 0.1% wt/wt OMG ointment and the other receiving ointment base (base). Rats were killed at one, three and seven days after surgery for histological and immunohistochemical observation. Compared with base group samples, OMG samples displayed enhanced capillary formation on anti-laminin-stained sections from day-3 specimens and a greater quantity of collagen fibers on Azan-Mallory-stained sections from day-7 specimens. Results were quantified using an automatic computerized pixel image analyzer. Hematoxylin-eosin-stained sections revealed that the length of regenerated junctional epithelium was shorter in the OMG group than in the base group. The data indicate that the application of OMG to surgical wounds accelerated fibroblast growth, collagen deposition, and capillary formation in granulation tissue. Thus, OMG could be a useful healing promoter for flap surgery.</p>","PeriodicalId":77319,"journal":{"name":"Periodontal clinical investigations : official publication of the Northeastern Society of Periodontists","volume":"14 2","pages":"13-22"},"PeriodicalIF":0.0000,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Periodontal clinical investigations : official publication of the Northeastern Society of Periodontists","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

The effects of ovomacroglobulin (OMG), an alpha 2-macroglobulin-like protease inhibitor, were tested on periodontal surgical would healing in 60 Wistar rats. The animals were divided into two groups, one receiving topical application of 0.1% wt/wt OMG ointment and the other receiving ointment base (base). Rats were killed at one, three and seven days after surgery for histological and immunohistochemical observation. Compared with base group samples, OMG samples displayed enhanced capillary formation on anti-laminin-stained sections from day-3 specimens and a greater quantity of collagen fibers on Azan-Mallory-stained sections from day-7 specimens. Results were quantified using an automatic computerized pixel image analyzer. Hematoxylin-eosin-stained sections revealed that the length of regenerated junctional epithelium was shorter in the OMG group than in the base group. The data indicate that the application of OMG to surgical wounds accelerated fibroblast growth, collagen deposition, and capillary formation in granulation tissue. Thus, OMG could be a useful healing promoter for flap surgery.

本刊更多论文

卵巨球蛋白对大鼠牙龈创面愈合的影响。

研究了α - 2巨球蛋白样蛋白酶抑制剂卵大球蛋白(omommacroglobulin, OMG)对60只Wistar大鼠牙周手术愈合的影响。动物被分为两组，一组接受0.1% wt/wt OMG软膏的局部应用，另一组接受软膏基础(base)。分别于术后1、3、7天处死大鼠进行组织学和免疫组化观察。与基群样品相比，OMG样品在第3天的抗层粘连蛋白染色切片上显示出增强的毛细血管形成，在第7天的azan - mallory染色切片上显示出更多的胶原纤维。使用自动计算机化像素图像分析仪对结果进行量化。苏木精-伊红染色切片显示，OMG组再生的连接上皮的长度比碱组短。数据表明，OMG在外科伤口中的应用加速了肉芽组织中成纤维细胞的生长、胶原沉积和毛细血管的形成。因此，OMG可能是皮瓣手术中有用的愈合促进剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Periodontal clinical investigations : official publication of the Northeastern Society of Periodontists

自引率

0.00%

发文量