Biological Evaluation of Pyrrolo [3, 2-d] pyrimidine Derivatives as Antibacterial Agents against Pathogenic Bacteria

Abstract

Background: Pyrimidine molecules' biological and chemotherapeutic importance in the medicinal world has been overlooked in many reports. We have previously synthesized new series of pyrrolo [3,2-d]pyrimidine derivatives (4a-4f) and here, we evaluate the antibacterial activity of these derivatives against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Salmonella bacteria. Materials and Methods: The agar well diffusion and agar dilution methods were used for determining inhibition zone diameter and minimum inhibitory concentration during preliminary evaluation of antimicrobial activity against gram-positive and gram-negative bacteria. Statistical analysis using Microsoft Excel 2010 was based on three independent experiments and the results were expressed as mean. Results: Some of the synthesized compounds exhibited antibacterial activity against the tested bacteria. Conclusion: Our findings indicate the antibacterial potential of the six novel synthetic pyrrolo[3,2-d]pyrimidine compounds.