The neuroprotective effects of intravascular low level laser irradiation on cerebral ischemia rats

Abstract

The effects of intravascular low level laser irradiation of He-Ne on rat MCAo-induced cerebral injury were studied. The results showed that control rats (subjected to MCAo injury without laser treatment) at 7d exhibited striatal and cortical brain infarction in the right hemisphere from approximately 3 to 11mm from the front pole. the total infarct volume in this group was 34.5±8.1mm3. For experimental rats (with laser management), the total infarct volume was 29.0±9.0mm3. P was gained less than 0.05. The neurological score of control group was 4.7±0.6 and it was 5.2±1.0 in experimental group, comparison by statistical analysis showed P less than 0.05. The cerebral pathological damages in the control group were more severe than in experimental group. We concluded that the intravascular low level laser irradiation has no remarked complication and is helpful to reduce ischemic damage. There is clinically potential for the application of intravascular He-Ne low level laser irradiation in ischemia stroke.