Pacellation method based on brain cortical morphological aging trajectory in normal cohorts

Jing Xia
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Abstract

The brain goes through various anatomical changes with age. These alterations are a result of ageing naturally. A more profound comprehension of these typical changes is crucial for separating them from pathogenic ones. In this study, we exhibit the ageing trajectories of cortical morphology by using cortical thickness from 55 to 85 years old. To explore the ageing hierarchical pattern, the whole cortex is divided into different regions with similar ageing trajectories. To construct the similarity matrix, we computed Pearson’s correlation coefficient between the cortical thickness of any paired vertices on the cortical surface. Then, we applied the parcellation method based on the similarity matrix on 490 normal middle-aged and old adults from 55 to 85 years old, and achieved meaningful hierarchical parcellation ageing maps based on cortical ageing trajectory. We then fit the ageing trajectory of the cortical thickness in each cluster. The results indicate that the rapid thinning regions in clusters are related to the temporal cortex and prefrontal cortices, while slowly thinning regions in clusters are related to the insula and medial occipital cortices. Importantly, our generated parcellation ageing maps indicate the hierarchical ageing patterns of normal middle-age and old adults, which is essential in disease diagnosing related to neurodegeneration and can help understand the ageing process.
基于正常人群脑皮层形态老化轨迹的分组方法
随着年龄的增长,大脑会经历各种解剖学上的变化。这些变化是自然老化的结果。更深刻地理解这些典型变化对于将它们与致病变化区分开来至关重要。在这项研究中,我们通过使用皮质厚度从55岁到85岁来展示皮质形态的衰老轨迹。为了探索衰老的分层模式,将整个皮层划分为具有相似衰老轨迹的不同区域。为了构造相似矩阵,我们计算了皮质表面上任何配对顶点的皮质厚度之间的Pearson相关系数。在此基础上,对490名55 ~ 85岁的正常中老年人进行了相似矩阵分割,得到了有意义的基于皮层衰老轨迹的分层分割衰老图。然后,我们拟合每个簇的皮质厚度的老化轨迹。结果表明,脑簇中快速变薄的区域与颞叶皮层和前额叶皮层有关,而缓慢变薄的区域与脑岛皮层和枕叶内侧皮层有关。重要的是,我们生成的包裹老化图显示了正常中老年人的分层老化模式,这在与神经变性相关的疾病诊断中是必不可少的,可以帮助理解衰老过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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