Degeneration of Granule Neurons In The Dentate Gyrus (Dg) Area In The Hippocampus In Male Rats Under The Influence of Simvastatin

Abstract

Background: Simvastatin is a lipophilic statin used to prevent and treat hypercholesterolemia. This study aimed to evaluate the effect of simvastatin on the appearance specifications of the DG region Hippocampus. Method: For the experiment, 36 male Wistar rats with an average weight of 300-250 g were divided into six groups (each group comprised six heads). Groups: 1): Control group, 2): Vitamin D dose 5 µg/kg, 3): Simvastatin group dose 1 mg/kg, 4): Simvastatin group dose 10 mg/kg, 5): Simvastatin group dose 1 mg/kg + vitamin D dose 5 µg/kg, 6): Simvastatin group dose 10 mg/kg + vitamin D dose 5 µg/kg. The duration of drug use was 28 days. At the end of the drug administration period, the animals were slaughtered, and then the brain tissue of the animals was extracted to prepare microscopic sections. Results: Microscopic studies show a negative effect of 10 mg/kg simvastatin on DG neurons. Conclusion: The microscopic studies in the present study indicate that high doses of simvastatin cause degeneration of neurons in the DG region of the hippocampus.