[Neuroleptic malignant syndrome associated with the inadequate antidiuretic hormone secretion syndrome].

Archivos de neurobiologia Pub Date : 1992-03-01
M García Escrig, F Bermejo Pareja, O Soto Téllez, J Díaz Guzmán, A Lledó
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引用次数: 0

Abstract

Neuroleptic malignant syndrome (NMS) is an adverse reaction of an idiosyncratic nature to drugs having antidopaminergic activity. Pathogenesis is largely disputed. An NMS case is presented which was triggered by flupentixol and was associated with severe hyponatremia (116 mmol/l upon admission). Both clinically and analytically, the hyponatraemia fulfills criteria to be considered secondary to an inappropriate secretion of antidiuretic hormone (SIADH). Other possible causes of hyponatraemia were ruled out. After early treatment with dopaminergic agonists and water restriction, both conditions improved in parallel. The different pathogenetic possibilities which may explain the temporal coexistence of both syndromes in the same patient are discussed. The association of these two conditions is in favour of a probable central pathogenetic cause for NMS. On the other hand, it is suggested that hyponatraemia may mask the diagnosis of NMS.

[与抗利尿激素分泌不足综合征相关的抗精神病药恶性综合征]。
抗精神病药恶性综合征(NMS)是一种特殊性质的不良反应的药物具有抗多巴胺能活性。发病机制在很大程度上存在争议。本文报告1例由氟哌噻醇引发的NMS病例,并伴有入院时116 mmol/l的严重低钠血症。从临床和分析角度来看,低钠血症符合继发于抗利尿激素(SIADH)分泌不当的标准。其他可能导致低钠血症的原因已被排除。在早期使用多巴胺能激动剂和限水治疗后,两种情况并行改善。不同的致病可能性,可能解释这两种综合征在同一病人的时间共存进行了讨论。这两种情况的关联有利于NMS可能的中心发病原因。另一方面,低钠血症可能掩盖NMS的诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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