Synthesis and characterization of ²-cyclodextrin-grafted chitosan derivatives on its mucoadhesion and antibacterial activities

Abstract

The aims of this study were to synthesize and determine the biological activities of two types of water-soluble βCD-grafted chitosan derivatives; βCD-grafted chitosan with spacer (QCDCA22-g-CS) and βCD-grafted chitosan without spacer (QCD23-g-CS) as a novel biomaterial for mucosal delivery. Difference in their chemical structure were defined by 1H-NMR According to mucin particle method, QCD23-g-CS showed stronger mucoadhesion towards mucin. Although both QCDCA22-g-CS and QCD23-g-CS demonstrated high antibacterial activity towards Candida albicans at 24 hours, QCD23-g-CS demonstrated much higher activity than QCDCA22-g-CS.