On the issue of revising the regulatory framework for chemical carcinogens in the air according to the risk criterion

Abstract

The aim of the work was to analyze the risk of carcinogenic substances in populated areas and industrial zone, included in domestic regulatory frameworks, in accordance with international qualification standards, and to determine the safety level of existing hygienic standards for humans by specific oncogenic hazard criteria. Materials and methods. Bibliosemantic, bibliographic and hygienic research methods was used in the work. The results were obtained on the basis of collection and analysis of data on chemical carcinogenic compounds that are dangerous to humans, according to international directives, domestic and foreign regulatory frameworks. Carcinogenicity indicators was identified to assess the hazards of certain substances and hygienic regulatory levels. Research results and their discussion. The analysis of national and international databases on carcinogenic compounds, assessment of their physicochemical properties, dose-effect response and health effects was carried out. It was shown that today the most recognized and widespread base of the International Agency for Research on Cancer, in which based on a critical analysis of experimental and epidemiological data of more than 1000 chemical factors, their classification was carried out according to the degree of evidence of carcinogenic hazard to humans, the hygienic expression of which is carcinogenic risk. The analysis of domestic databases of hygienic standards for the permissible content of chemicals showed that only for 131 carcinogenic substances the MPC in the air is justified, however, according to the criterion of carcinogenic risk, most of them do not meet the requirements of the EU and world practices, which indicates the need for their revision. It is emphasized that one of the available and adequate methods of this task is the principle laid down in determining the relationship "concentration - risk (acceptable risk)". Conclusions. It was shown that according to the criterion of carcinogenic risk, the hygienic standards of most carcinogenic substances included in domestic regulatory air bases do not meet the requirements of the EU and international practices, which indicates the need to revise them based on acceptable risk.