Effect of short-term starvation and water deprivation on pharmacokinetics of antipyrine in calves.

Abstract

The experiment was carried out on 15 calves of black and white breed at the age of 21-22 days. The effect of 72 hours simultaneous starvation and water deprivation on pharmacokinetics of antipyrine (phenazone) was studied. The following parameters were determined: Vd--volume of distribution, delta Vd--apparent volume of distribution, t0.5--half-life, ClA--metabolic clearance rate. There were shown statistically significant increase of half-life and decrease of metabolic clearance rate and volume of antipyrine distribution in fasted and water deprived calves. Apparent volume of antipyrine distribution in the control and experimental groups did not differ significantly. The obtained results indicate that starvation and water deprivation considerably inhibits liver biotransformation process (estimated on the basis of antipyrine test) in calves during neonatal period.