A.Gregory Bruce , Peter S. Linsley , Timothy M. Rose
{"title":"Oncostatin M","authors":"A.Gregory Bruce , Peter S. Linsley , Timothy M. Rose","doi":"10.1016/0955-2235(92)90029-H","DOIUrl":null,"url":null,"abstract":"<div><p>Oncostatin M (OSM) was initially identified as a polypeptide cytokine which inhibited the <em>in vitro</em> growth of cells from melanoma and other solid tumors. OSM shows significant similarities in primary amino acid sequence and predicted secondary structure to leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), granulocyte colony-stimulating factor (G-CSF), interleukin 6 (IL-6), and interleukin 11 (IL-11). Analysis of the genes encoding these proteins reveals a shared exon organization suggesting evolutionary descent from a common ancestral gene. Recent data indicates that OSM also shares a number of <em>in vitro</em> activities with other members of this cytokine family. The overlapping biological effects appear to be explained by the sharing of receptor subunits.</p></div>","PeriodicalId":77335,"journal":{"name":"Progress in growth factor research","volume":"4 2","pages":"Pages 157-170"},"PeriodicalIF":0.0000,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0955-2235(92)90029-H","citationCount":"19","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in growth factor research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/095522359290029H","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 19
Abstract
Oncostatin M (OSM) was initially identified as a polypeptide cytokine which inhibited the in vitro growth of cells from melanoma and other solid tumors. OSM shows significant similarities in primary amino acid sequence and predicted secondary structure to leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), granulocyte colony-stimulating factor (G-CSF), interleukin 6 (IL-6), and interleukin 11 (IL-11). Analysis of the genes encoding these proteins reveals a shared exon organization suggesting evolutionary descent from a common ancestral gene. Recent data indicates that OSM also shares a number of in vitro activities with other members of this cytokine family. The overlapping biological effects appear to be explained by the sharing of receptor subunits.
Oncostatin M (OSM)最初被确定为一种多肽细胞因子，可以抑制黑色素瘤和其他实体瘤细胞的体外生长。OSM与白血病抑制因子(LIF)、纤毛神经营养因子(CNTF)、粒细胞集落刺激因子(G-CSF)、白细胞介素6 (IL-6)和白细胞介素11 (IL-11)在初级氨基酸序列和预测二级结构上有显著的相似性。对编码这些蛋白质的基因的分析揭示了一个共同的外显子组织，表明从一个共同的祖先基因进化而来。最近的数据表明，OSM还与该细胞因子家族的其他成员共享许多体外活性。重叠的生物学效应似乎可以用受体亚基的共享来解释。
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
