The influence of normobaric hyperoxia on anti-oxidant enzymes activities and peroxidation product levels in rat lungs.

Abstract

The aim of this study was to investigate superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase and glucose-6-phosphate dehydrogenase as well as malondialdehyde, conjugated dienes and hydroperoxide levels in rat lungs after 12-, 24-, and 48-h normobaric hyperoxia. It was stated that activities of the above-mentioned enzymes and peroxidation products are increased as early as after 12 hours of hyperoxia. It is suggested that normobaric hyperoxia can induce anti-oxidant enzymes and lipid peroxidation as early as in 12th hour of hyperoxia.