[The osmotic regulation of gastrin secretion by the isolated rat duodenum].

Abstract

Activating effect of osmotic irritant agent was suppressed by N- and M-cholinoblocking agents, benzohexonium and pyrenzepine in the rat isolated duodenum. The same was true for phentolamine and not for obsidan. The data obtained suggest that the osmotic regulation of the gastrin secretion is performed through the mechanism of a local intramural reflex with participation of N- and M-cholinoreactive and alpha-adrenoreactive agents.