VITAMIN D SUPPLEMENTATION AND FUNCTIONAL KNEE OSTEOARTHRITIS PROGRESSION IN OLDER ADULTS WITH OBESITY: DATA FROM THE OSTEOARTHRITIS INITIATIVE

A. Zbehlik, L. Barre, J. Batsis, E. Scherer, S. Bartels
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Abstract

Objective: Older adults with obesity are at increased risk of knee osteoarthritis (KOA) and vitamin D deficiency, but data on the effect of vitamin D supplementation in this population are equivocal. This study evaluated the effect of vitamin D supplementation on functional progression of KOA in older adults with obesity. Participants with Body Mass Index ≥30 kg/m2 and aged ≥ 60 years from the Osteoarthritis Initiative progression cohort were stratified by baseline vitamin D use. The relationship between vitamin D supplementation and progression of KOA at 72 months was characterized. The Western Ontario McMaster University Osteoarthritis Index (WOMAC) pain scale was the primary outcome measure. Secondary measures included: WOMAC disability, Physical Activity Scale for the Elderly, gait speed and Knee injury and Osteoarthritis Outcome Score (KOOS) scales. In older adults with KOA and obesity, baseline supplemental vitamin D use did not predict functional progression of osteoarthritis at 72 months.
老年肥胖患者补充维生素d和功能性膝骨关节炎进展:来自骨关节炎倡议的数据
目的:肥胖老年人患膝骨关节炎(KOA)和维生素D缺乏症的风险增加,但维生素D补充对这一人群的影响数据尚不明确。本研究评估了补充维生素D对老年肥胖患者KOA功能进展的影响。体重指数≥30kg /m2、年龄≥60岁的骨关节炎进展队列参与者按基线维生素D使用情况分层。研究了维生素D补充与KOA在72个月时进展的关系。西安大略麦克马斯特大学骨关节炎指数(WOMAC)疼痛量表是主要的结局指标。次要测量包括:WOMAC残疾、老年人体力活动量表、步态速度和膝关节损伤和骨关节炎结局评分(oos)量表。在患有KOA和肥胖的老年人中,基线补充维生素D的使用并不能预测骨关节炎72个月时的功能进展。
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