NEUROENDOCRINE NEOPLASMS IN ITALY

Annals of Research in Oncology Pub Date : 2021-12-01 DOI:10.48286/aro.2021.14

L. Mangone, I. Bisceglia, C. Sacchettini, P. Mancuso, G. Carlinfante, P. Giorgi Rossi, A. AIRTUM Working Group

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引用次数: 1

Abstract

Neuroendocrine neoplasms (NENs) account for 0.5% of all neoplasms worldwide. The aim of the study was to describe the epidemiology of NENs in Italy and the association with a second neoplasm using the Italian Cancer Registries (AIRTUM) database. Thirty-eight cancer registries were involved in this study in the period 1976-2012. The standardized incidence rates and the relative 5-year survival are reported. Cases by site, sex, and age, and the second cancers associated with patients with NENs are described. A total of 9,707 NENs were reported to the AIRTUM database: 5,318 males (54.8%) and 4,389 females (45.2%). Lung and small intestine were the most frequent sites in both sexes. The standardized incidence increased from 1 case per 100,000/year (1976) to 5.46 case per 100,000/year in 2010 (95% CI 4.90-6.06), with a significant difference between 1 Epidemiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy 2 Department of Medical Sciences, University of Turin, Turin, Italy 3 Pathology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy 4 Associazione Italiana Registri Tumori (AIRTUM), Italy CORRESPONDING AUTHOR: Lucia Mangone Epidemiology Unit AUSL–IRCCS di Reggio Emilia via Amendola 2 42122 Reggio Emilia, Italy E-mail: mangone.lucia@ausl.re.it ORCID: 0000-0003-4850-2678 Doi: 10.48286/aro.2021.14 History Received: Mar 25, 2021 Accepted: Apr 6, 2021 Published: Jun 1, 2021 L. Mangone 1, I. Bisceglia 1, C. Sacchettini 2, P. Mancuso 1, G. Carlinfante 3, P. Giorgi Rossi 1, AIRTUM Working Group 4 NEUROENDOCRINE NEOPLASMS IN ITALY rates in males (6.51, 95% CI 5.61-7.51) and in females (4.60, 95 CI 3.91-5.37). Incidence increased gradually in both sexes up to age 40-45, after which it increased rapidly. The 5-year relative survival was 59.7% (53.9% in males and 66.5% in females). NEN patients had a slight, not significant excess risk of having a second tumour: standardized incidence ratio 1.06 (95% CI 0.98-1.15). Of the 9,707 NENs studied, 2,033 (21%) had a second neoplasm: among these, 29 were NENs, 1,360 were other previous tumours, and 644 were other following tumours (78 synchronous and 566 metachronous tumours). Although traditionally thought to be rare, incidence has increased by nearly sevenfold since 1976. Differences in registration accuracy and classification criteria challenge comparisons between areas and time. Annals of Research in Oncology Vol. 1(2), 119-129, 2021

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意大利的神经内分泌肿瘤

神经内分泌肿瘤(NENs)占全球所有肿瘤的0.5%。该研究的目的是利用意大利癌症登记处(AIRTUM)数据库描述意大利NENs的流行病学及其与第二种肿瘤的关系。在1976年至2012年期间，38个癌症登记处参与了这项研究。报告标准化发病率和相对5年生存率。按部位、性别和年龄分类的病例以及与NENs患者相关的第二种癌症进行了描述。AIRTUM数据库共报告了9707例NENs，其中男性5318例(54.8%)，女性4389例(45.2%)。肺和小肠是两性中最常见的部位。标准化发病率从1976年的1例/ 10万/年增加到2010年的5.46例/ 10万/年(95% CI 4.90-6.06)，其中1个流行病学单位，意大利雷焦艾米利亚地区联合医院- irccs，意大利雷焦艾米利亚，意大利都灵大学医学系，意大利都灵3个病理单位，意大利雷焦艾米利亚地区联合医院- irccs，意大利雷焦艾米利亚，意大利雷焦艾米利亚，4意大利肿瘤登记协会(AIRTUM)，通讯作者:Lucia Mangone流行病学单位AUSL-IRCCS di Reggio Emilia via Amendola 2 42122 Reggio Emilia, Italy E-mail: mangone.lucia@ausl.re.it ORCID: 0000-0003-4850-2678 Doi: 10.48286/aro.2021.14接收时间:2021年3月25日接收时间:2021年4月6日发布时间:L. Mangone 1, I. Bisceglia 1, C. Sacchettini 2, P. Mancuso 1, G. Carlinfante 3, P. Giorgi Rossi 1, AIRTUM工作组4意大利神经内分泌肿瘤发病率男性(6.51,95% CI 5.61-7.51)，女性(4.60,95% CI 3.91-5.37)。在40-45岁之前，男女发病率逐渐增加，之后迅速增加。5年相对生存率为59.7%(男性53.9%，女性66.5%)。NEN患者有轻微但不显著的第二肿瘤额外风险:标准化发病率比1.06 (95% CI 0.98-1.15)。在研究的9,707例nen中，2,033例(21%)患有第二肿瘤:其中29例为nen, 1,360例为其他既往肿瘤，644例为其他后续肿瘤(78例为同步肿瘤，566例为异时肿瘤)。虽然传统上认为罕见，但自1976年以来发病率增加了近7倍。注册精度和分类标准的差异对区域和时间之间的比较提出了挑战。中国肿瘤学杂志Vol. 1(2)， 119-129, 2021

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Annals of Research in Oncology

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