Routine production and quality control of 123I-labelled mIBG at NAC

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-10-01 DOI:10.1016/0883-2889(92)90211-V

D. Du T. Rossouw

引用次数: 8

Abstract

An existing method, developed in our laboratory, has been further improved for the large scale routine production of [¹²³I]mIBG. Losses of ¹²³I during production have been decreased from 16% to <3% and labelling efficiencies of >98% are now consistently obtained. A sensitive HPLC quality control method for [¹²³I]mIBG, based on reverse-phase ion-pair chromatography, has also been developed.

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123i标记mIBG的常规生产及质量控制

我们实验室开发的一种现有方法已进一步改进，用于大规模常规生产[123I]mIBG。在生产过程中，123I的损耗从16%降至3%，标签效率一直保持在98%。建立了一种基于反相离子对色谱法的[123I]mIBG灵敏的HPLC质量控制方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes

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