Prevalence of Multi-Drug Resistance Bacteria among Adult Chronic Dacryocystitis Cases in Rajshahi Medical College Hospital

Abstract

Background: Chronic dacryocystitis is a common ophthalmological problem in Bangladesh. Clinicians need to prescribe antibiotics to patients as an early conservative treatment protocol and, for prevention of post-operative soft tissue infections. But in most of the cases, the empiric antibiotic therapy shows treatment failure and, consequent development of complications, which might be due to emergence and spread of Multi-Drug-Resistant (MDR) organisms. Objectives: The objective of this study was to detect the prevalence rates of MDR organisms among adult chronic dacryocystitis cases, so that preventive measures can be undertaken in advance to stop its further spread. Methods: A cross sectional descriptive type of study was carried out in the ophthalmology inpatient department of Rajshahi Medical College Hospital (RMCH), a tertiary care government teaching hospital, from January to December, 2017. One hundred diagnosed cases of chronic dacryocystitis undergoing DCR operation were selected and lacrimal sac swabs were collected from each of them. Isolation and identification of bacteria and their antibiotic sensitivity tests were done by standard procedures in the microbiology laboratory of the college. MDR bacteria were detected according to CDC (Centers for Disease Control and Prevention) and ECDC (European Centre for Disease Prevention and Control) guidelines. Results: Of the 100 swabs, 73% were culture-positive and, of them, 72.59% were gram-positive and the rest were gram-negative. None of the gram-positive isolates were MDR, but 70% of the gram-negative isolates were MDR. Conclusion: This study provided an early insight into the prevalence of MDR organisms among chronic dacryocystitis cases in the RMCH. The results might be beneficial for the therapeutic approach and prevention of MDR spreading in the ophthalmology wards of all hospitals.