Quadratic phase coupling in auditory evoked potentials from healthy old subjects and subjects with Alzheimer's dementia

[1993 Proceedings] IEEE Signal Processing Workshop on Higher-Order Statistics Pub Date : 1993-06-07 DOI:10.1109/HOST.1993.264535

V. Samar, K. Swartz, M. Raghuveer, A.L. Braveman, J.M. Centola, J.K. Jackson

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引用次数: 8

Abstract

Auditory evoked potentials (EPs) were recorded from healthy old (mean age 70) and Alzheimer's (mean age 75) subjects in four experimental oddball series. In three series, targets occurred randomly with global probabilities of 20, 50 and 80%. In the fourth series, targets occurred predictably every fifth tone (20% global probability). EPs were recorded at Fz, Cz, Pz, and left and right temporo-parietal sites. Bicoherence analyses revealed that quadratic phase coupling occurred in the EPs in the classic delta, theta, alpha, and beta EEG frequency bands. Quadratic phase coupling patterns displayed a fronto-central topography and varied directly with global stimulus probability. The data suggest an inverse relationship between P300 amplitude and degree of quadratic phase coupling in the delta band. Quadratic phase coupling patterns were altered in Alzheimer's patients. This is the first demonstration that task-dependent quadratic nonlinearities can be detected in transient evoked potentials.<>

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老年健康受试者与老年痴呆受试者听觉诱发电位的二次相耦合

对健康老年人(平均年龄70岁)和老年痴呆症患者(平均年龄75岁)的听觉诱发电位(EPs)进行了记录。在三个系列中，目标随机出现，总体概率分别为20%、50%和80%。在第四个系列中，目标可预测地每五个音调发生一次(全球概率为20%)。在Fz、Cz、Pz和左、右颞顶叶部位记录EPs。双相干分析表明，在典型的δ、θ、α和β脑电图频带中，EPs存在二次相位耦合。二次相位耦合模式表现为前缘-中心地形，并与全局刺激概率直接变化。数据表明P300振幅与δ波段的二次相位耦合程度成反比关系。阿尔茨海默病患者的二次相耦合模式发生了改变。这是第一次证明在瞬态诱发电位中可以检测到任务相关的二次非线性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[1993 Proceedings] IEEE Signal Processing Workshop on Higher-Order Statistics

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