The effect of stevia sweetener on diabetic nephropathy in rats

THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology) Pub Date : 1900-01-01 DOI:10.5455/egysebz.20220803073155

A. Marei, Doaa Mahmoud

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Abstract

Diabetic nephropathy (DN) is considered a clinical syndrome, which is a diabetic kidney disease characterized by increasing blood pressure, albuminuria, and chronic kidney disease. The current study aimed to determine the effect of sweetener (Stevia rebaudiana ) on diabetic nephropathy in a diabetic rat model. Four groups (n=7) of male albino rats (Rattus norvegicus): the control group, diabetic control group (induced streptozotocin intraperitoneally), two diabetic rat groups treated with 2 doses of stevia (200 and 400 mg/kg body weight) for 4 weeks. Biomarkers of nephropathy were measured in plasma and kidneys at the end of the experiment. The levels of plasma glucose, urea, uric acid, creatinine, renal malondialdehyde (MDA), and caspase-3 significantly increased in diabetic rats and levels of insulin, renal catalase, superoxide dismutase, and vascular endothelial growth factor A (VEGF-A) were significantly decreased. After treating the diabetic rats with natural sweetener (stevia), the kidney and plasma biochemical parameters were improved significantly. These results indicated the major role of stevia in diabetic nephropathy.

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甜叶菊甜味剂对大鼠糖尿病肾病的影响

糖尿病肾病(Diabetic nephropathy, DN)被认为是一种临床综合征，是一种以血压升高、蛋白尿和慢性肾脏疾病为特征的糖尿病肾病。目前的研究旨在确定甜味剂(甜菊糖)对糖尿病大鼠模型糖尿病肾病的影响。雄性白化大鼠(褐家鼠)4组(n=7):对照组、糖尿病对照组(腹腔注射链脲佐菌素)、2个糖尿病大鼠组分别给予2剂甜叶菊(200、400 mg/kg体重)治疗4周。在实验结束时，在血浆和肾脏中测量肾病的生物标志物。糖尿病大鼠血浆葡萄糖、尿素、尿酸、肌酐、肾丙二醛(MDA)、caspase-3水平显著升高，胰岛素、肾过氧化氢酶、超氧化物歧化酶、血管内皮生长因子A (VEGF-A)水平显著降低。用天然甜味剂甜叶菊治疗糖尿病大鼠后，肾脏和血浆生化指标均有明显改善。这些结果表明甜叶菊在糖尿病肾病中的主要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Zoology)

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