Neutrophil Lymphocyte Ratio and C-Reactive Protein in Nondialysis Chronic Kidney Disease

Abstract

Background: Chronic kidney disease (CKD) occurs when a disease or condition impairs kidney function, causing kidney damage to worsen over several months. Inflammatory markers such as C-reactive protein (CRP), Interleukine are widely used in CKD. However, those traditional biomarkers have their limitations because of its measurement is costly or inaccessible. Recently, the Neutrophil-to-lymphocyte ratio (NLR) was reported to be associated with inflammation in End-stage renal disease (ESRD). Its measurement is simpler and cheaper4.5. The aim of the present study was to determine whether NLR is associated with CRP in CKD patients. Methods: This cross-sectional and observational analytic study was conducted 12 consecutive Pre Hemodialysis patients ESRD between Mei 2021 and Augustus 2021. Subjects were divided into two groups according to the results of the examination of the CRP and NLR levels. Then analyzed whether there is have a correlation. Results: The composite endpoint was observed in 12 patients with ESRD; it was found that both of the values of NLR and CRP were equally increased in ESRD patients, although they were not statistically significant. Conclusion: The present study demonstrated that a high NLR in ESDR and suggesting that NLR may be a useful marker for the prediction of infection in patients with CKD.