Malignant phylloides with heterologous elements: A case report

Manish Kumar Pradhan, Sumanlata Sahu, Kanchan Maurya, Marisha, Vikas Kailashiya
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Abstract

Phyllodes tumor of the breast is an uncommon biphasic tumor, occurring mainly in females belonging to the age group of 42 to 45 years. Malignant phyllodes tumor is a rare neoplasm that accounts for 10 to 20% of total phyllodes tumors. Histologically, phyllodes tumors are featured by leaf like projections of hypercellular stroma into the cystic or cleft-like spaces being lined by epithelium. Presence of stromal elements like fibrosarcomatous and heterologous sarcomatous characters are associated with an increased risk of malignant change. Here, we report a rare case of a 50yrs old female patient, who presented with swiftly growing left breast mass that was diagnosed as a case of malignant phyllodes tumor showing heterologous elements in form of chondroid, liposarcomatous, rhabdoid and fibrosarcoma, with marked proliferation of stromal component. The patient was subjected to modified radical mastectomy.
异源性叶状瘤1例
乳腺叶状瘤是一种少见的双相肿瘤,多见于42 ~ 45岁的女性。恶性叶状瘤是一种罕见的肿瘤,约占总叶状瘤的10% ~ 20%。组织学上,叶状瘤的特征是叶状的高细胞间质向上皮排列的囊状或裂隙状间隙内突出。间质成分如纤维肉瘤和异源肉瘤特征的存在与恶性变化的风险增加有关。在此,我们报告一例罕见的50岁女性患者,她表现为快速增长的左乳房肿块,被诊断为恶性叶状瘤,表现为软骨样、脂肪肉瘤、横纹肌样和纤维肉瘤等异体成分,间质成分明显增生。患者接受改良乳房根治术。
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