Magnetic Hyperthermia using G-Protein Coating in Molecular Communications

Abstract

Magnetic hyperthermia is a type of cancer treat-ment using a magnetic nanoparticle drug carrier to transform external electromagnetic energy into induction heating in the targeted tumor region. This paper investigates passive molecular communication via diffusion channels using a series of computer simulations to calculate the number of receive molecules and bit-error-rate (BER) performance to indicate the quality of the communication. After the reception of the molecules in the targeted tumor, the simulation of magnetic hyperthermia with various parameters include the shape, size, coating material, and thickness of the nanoparticle using COMSOL to calculate the highest achievable temperature, distribution of bioheat, and the amount of damage area regarding the surrounding healthy tissue. We found that: (i) sufficient parameters, such as distance between the transmitter and the receiver, number of emitting molecules, threshold at the receiver, and diffusion coefficient influence the error probability, (ii) binary Molecular Shift Keying (BMoSK) modulation produces better BER performances than that of Binary Concentration Shift Keying (BCSK) modulation, and (iii) the proposed G-protein coating for the magnetic nanoparticle performs the same behavior as the polymer that provide the highest achievable temperature, evenly distributed bioheat, and decreases the amount of damage on the healthy tissue region.