[The use of hypoxic stimulation in chronic and relapsing bronchitis in young children ].

Fiziologicheskiĭ zhurnal Pub Date : 1992-09-01
M S Fesenko, T O Lysiana
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Abstract

214 children of different age with various forms of bronchitis were subject to immunological and biochemical examination. Against a background of hypoxic state of patients the values of quantitative indices of cellular immunity (E-RFC, blast-transformation reaction with phytohemagglutination) were revealed to decrease and dysimmunoglobulinemia-to form. It is shown that in the period of exacerbation of clinical symptoms of bronchitis the concentration of malonic dialdehyde and resistance of erythrocyte membranes to peroxide hemolysis significantly increase. Analysis of peroxidation level against a background of improvement of clinical indices after the performed treatment indicates that there is no tendency to normalization of metabolic disorders. The above results show that it is necessary to carry out normobaric hypoxic stimulation aimed at treating and preventing bronchitis in children of early age.

[低氧刺激在儿童慢性和复发性支气管炎中的应用]。
对214例不同年龄、不同类型支气管炎患儿进行了免疫学和生化检查。在患者缺氧的背景下,细胞免疫定量指标(E-RFC、植物血凝细胞转化反应)下降,免疫球蛋白生成障碍。结果表明,在支气管炎临床症状加重期,丙二醛浓度和红细胞膜对过氧化物溶血的抵抗力显著增高。在治疗后临床指标改善的背景下,对过氧化水平的分析表明,代谢紊乱没有正常化的趋势。以上结果表明,开展以治疗和预防早期儿童支气管炎为目的的常压低氧刺激是必要的。
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