Serotonin concentration in offspring of parents suffering from premature coronary arterial disease.

Abstract

Thirty-one 3 to 14 years old offspring of parents who had an acute myocardial infarction before age of 45 and 42 healthy children without any family history of cardiovascular disease were investigated. A significant increase in plasma free serotonin concentration was seen in endangered children. From these results it may be supposed that vascular endothelium is dysfunctional in offspring of parents suffering from premature coronary arterial disease.