Endocrine and metabolic complications of advanced cancer

Abstract

This chapter covers the common endocrine and metabolic complications associated with malignancies such as hypercalcaemia, SIADH, and changes in glucose metabolism. It also outlines a strategy for managing the patient with iatrogenic hyperglycaemia as well as the patient with diabetes mellitus in the last phase of life. Metabolic and endocrinological disorders have a profound impact on a patient’s physical and psychological well-being. These disorders are at times complex, but it is important to be aware of the associated endocrine and metabolic complications in advanced cancer as they can have a significant impact on morbidity and mortality. In addition, even when the underlying cancer may not be responsive to treatment, such symptoms may be reversible, which can have a significant benefit to the individual patient.