Metabolic syndrome as a determinant of the complication of COVID-19 patients

Abstract

, diabetes, hypertension and dyslipidemia have been associated with greater severity and mortality in COVID-19; this establishes a possible relationship between metabolic syndrome and severity of COVID-19. The pathophysiological mechanisms by which these comorbidities contribute with a worse prognosis in patients with COVID-19 are not yet completely elucidated. Chronic inflammation contributes to immune system dysfunction and a prothrombotic state; furthermore, elevated levels of ECA2, the entry point for SARS-CoV-2, in the metabolic syndrome would be implicated. This review describes the theories that would explain the relationship between metabolic syndrome and COVID-19.