Amitriptyline as a reference antidepressant. r ational pharmacotherapy for depression with chronic pain and insomnia

Abstract

According to WHO, depressive disorders are 4 times more common among patients suffering from chronic pain with insomnia. Insomnia in depression complicated by pain is a clinical syndrome characterized by nocturnal sleep disorders and related disorders during daytime wakefulness, occurring even when there is sufficient time and conditions for sleep. Treatment of insomnia patients with amitriptyline, phenazepam, and bromocamphor reduced the average duration of hospitalization, improved the patients’ quality of life, and reduced the frequency of seeking neurological care.