Detection of creatine kinase isoenzymes as tumoral markers of rhabdomyosarcoma.

Enzyme Pub Date : 1992-01-01 DOI:10.1159/000468795
J E Fernández, F Rodríguez, M A Recio, C Vélez, A E Aránega, L Alvarez, A Aránega
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引用次数: 4

Abstract

We analyzed the expression profile of isoenzymatic fractions of creatine phosphokinase (EC 2.7.3.2) isotypes MM, MB and BB in three cell lines derived from embryonic rhabdomyosarcomas and a normal counterpart cell line. Electrophoretic data showed that the BB fraction was consistently expressed de novo, in contrast with its counterpart in normal tissue. The BB fraction may serve as new tumoral marker for the diagnosis of rhabdomyosarcoma. In addition, the appearance of macrocreatine kinase type-1 in this type of neoplasm may serve to reinforce the diagnosis when rhabdomyosarcoma is suspected.

肌酸激酶同工酶作为横纹肌肉瘤肿瘤标志物的检测。
我们分析了肌酸磷酸激酶(EC 2.7.3.2)同工酶组分MM、MB和BB在3个胚胎横纹肌肉瘤细胞系和一个正常对应细胞系中的表达谱。电泳数据显示,与正常组织中的BB部分相比,BB部分一致地从头表达。BB分数可作为诊断横纹肌肉瘤的新的肿瘤标志物。此外,当怀疑横纹肌肉瘤时,这种类型肿瘤中大肌酸激酶1型的出现可能有助于加强诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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