Evaluation of the effects of different progesterone treatment methods on fetal aneuploidy screening tests

Abstract

Objective In this study, the effect of progesterone use on biomarkers due to abortion complaints in aneuploidy screenings was investigated. Study Design Two hundred seventy-six singleton pregnant patients with threatened abortion were enrolled in this retrospective study. The treatment group consisted of patients who received oral, vaginal, or intramuscular progesterone (n=137) while the control group received no progesterone (n=139). The results of the double and triple screening tests of the study groups were compared. Results Nuchal translucency measurements and pregnancy-associated plasma protein-A (PAPP-A), (MoM) values were significantly lower in the group that received treatment with progesterone compared to the control group (p=0.009 and p