Development and Study of a Hybrid Tissue Scaffold Fabrication System for Neurotrophin Delivery

Abstract

Drug delivery to a biological system within the body requires precise control. Hybrid tissue scaffolds, manufactured via electrospinning, may be used in effective treatment of peripheral nerve damage. This study describes the development of such a scaffold, its characterization, and in vitro effectiveness; including the creation of an electrospinning apparatus capable of creating the tissue scaffold via coaxial spinning of biomaterials, material selection and testing, as well as mathematical modeling of the drug delivery profile.