Secure genomic susceptibility testing based on lattice encryption

Abstract

Recent advances in Next Generation Sequencing have increased the availability of genomic data for more accurate analyses, like testing for the genetic susceptibility to a disease. Current laboratories' facilities cannot cope with this data growth, and genomic processing needs to be outsourced, comprising serious privacy risks. This work proposes an encrypted genomic susceptibility test protocol based on lattice homomorphic cryptosystems, and introduces optimizations like data packing and transformed processing to achieve considerable gains in performance, bandwidth and storage needs.