Local Therapy Modalities in Management of Colorectal Cancer Liver Metastasis

Abstract

Colorectal cancers (CRC) are the third leading cause of cancer-related mortality in both genders in the United States [1]. In 2019, an estimated 145,600 adults will be diagnosed with CRC [1]. Up to 25% of CRC admit initially with colorectal liver metastasis (CRLM), and approximately 50% develop CRLM during the course of the disease. The stage 4 CRC has the lowest 5-year survival rates; 12 % for colon cancer, 13% for rectal cancer. Liver metastasectomy may improve overall survival, and these patients may have long-term relapse free survival. So the management of liver metastasis becomes more important. The local liver therapies can expand the options of management and improve outcomes for CRLM patients.