{"title":"Droplet Dynamics in Constricted Return Bends of Microfluidic Channels","authors":"Julie A. Melbye, Yechun Wang","doi":"10.1115/fedsm2020-20406","DOIUrl":null,"url":null,"abstract":"\n Microfluidic delivery systems have been employed to facilitate cell seeding procedures in drug development for personalized medicine for cancer patients. Despite of the high-throughput nature and potential impact on clinical outcomes of these systems, the efficiency in cell trapping remains a challenge in the operation. Droplet-based microfluidics became one of the solutions due to the large size of the cell-enclosing droplets and their interfacial properties. This study is focused on the motion of the cell-enclosing droplet in a constricted return bends that help to restrict the release of the cells while maintaining the high-throughput nature of the device. In this preliminary study, a three-dimensional boundary element method is used to predict droplet shape, deformation and migration velocity under the influence of various fluid properties and operational conditions. A variety of channel geometries have been explored as well. The resulting computational framework will be used to guide the design of a droplet-based microfluidic delivery system for cell seeding in 3D tumor spheroid arrays.","PeriodicalId":333138,"journal":{"name":"Volume 2: Fluid Mechanics; Multiphase Flows","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Volume 2: Fluid Mechanics; Multiphase Flows","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1115/fedsm2020-20406","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Microfluidic delivery systems have been employed to facilitate cell seeding procedures in drug development for personalized medicine for cancer patients. Despite of the high-throughput nature and potential impact on clinical outcomes of these systems, the efficiency in cell trapping remains a challenge in the operation. Droplet-based microfluidics became one of the solutions due to the large size of the cell-enclosing droplets and their interfacial properties. This study is focused on the motion of the cell-enclosing droplet in a constricted return bends that help to restrict the release of the cells while maintaining the high-throughput nature of the device. In this preliminary study, a three-dimensional boundary element method is used to predict droplet shape, deformation and migration velocity under the influence of various fluid properties and operational conditions. A variety of channel geometries have been explored as well. The resulting computational framework will be used to guide the design of a droplet-based microfluidic delivery system for cell seeding in 3D tumor spheroid arrays.