Green and Benign Strategies for Synthesis of Biologically Active Compounds using Lipase as Biocatalyst

Abstract

An efficient, feasible, mild, affordable, and environmentally friendly method has been developed for the  synthesis of biologically active compound 3-methylene-indoline-2-one from Isatin and active methylene  compounds using Lipase as a Green and Biocatalyst. Biological Processes are very important to  optimization to increase and improve the efficiency of cost. In this project, Malononitrile, or Dimedone  reacts with Isatin in presence of lipase. The essential features of this approach are metal-free reaction, high yield, nontoxic, and less hazardous. These reactions surpass metal-catalyzed processes because these  reactions have violent reaction conditions, toxic, less yields, complex workups, and environmentally  hazardous ingredients. This approach replaces hazardous chemicals with benign material during their  design, manufacture, use and disposal. Designing of product is cost-effective and environmentally benign  chemically products. It is completely followed to Green Approach. The entire given biologically active  compound have shown biological activities such as Antiviral, Anti-HIV, Antibacterial, and  Anticonvulsants.