Prevalence of Paroxysmal Nocturnal Haemoglobinuria Clone in Aplastic Anaemia: A Single Centre Study

Haematology Journal of Bangladesh Pub Date : 2023-03-20 DOI:10.37545/haematoljbd2023100

A. Haque, S. Nahar, A. Haque, Md. Arif-Ur- Rahman, A. Yunus, T. Afrin, Md. Abdul Aziz, Md. Rafiquzzaman Khan, Md Salahuddin Shah, Nusrat Jahan

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Abstract

Background: Flow cytometry assay for PNH clone is a compulsory routine test for all aplastic anaemia patients. Objective: To estimate the frequency of PNH clone in aplastic anaemia. Method: Twenty-two known cases of aplastic anaemia patients were enrolled for the study. Flow cytometric quantitation of glycosyl phosphatidyl-inositol (GPI)-anchored proteins deficiency using markers CD14, CD24, CD45, CD59, Fluorescent Aerolysin (FLAER), CD235a (6 markers) were performed. Result: PNH clone was identified in 8 (36.4%) of the study population. Among PNH clone positive patients 7 (87.5%) were suffering from non-severe aplastic anaemia. Conclusion: PNH clone is significantly associated with aplastic anaemia and PNH clone assay should be regularly assayed in aplastic anaemia patients for specific management.

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再生障碍性贫血患者阵发性夜间血红蛋白尿克隆的患病率:一项单中心研究

背景:流式细胞术检测PNH克隆是所有再生障碍性贫血患者的强制性常规检测。目的:探讨再生障碍性贫血中PNH克隆的发生频率。方法:选取22例已知再生障碍性贫血患者作为研究对象。用CD14、CD24、CD45、CD59、荧光气溶素(fler)、CD235a(6个标记)对糖基磷脂酰肌醇(GPI)锚定蛋白缺乏症进行流式细胞术定量。结果:8例(36.4%)被鉴定出PNH克隆。PNH克隆阳性患者中有7例(87.5%)患有非重度再生障碍性贫血。结论:PNH克隆与再生障碍性贫血有显著相关性，在再生障碍性贫血患者中应定期检测PNH克隆，以便进行针对性的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Haematology Journal of Bangladesh

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