Evaluation of Antipsoriatic Activity of Topical Curcumin by using Mouse Tail Model

Abstract

Assistant Prof. hadaf A. Aljunaeh. F.I.B.M.S dermatology*( hadaf.a@utq.edu.iq) Dr.hameed N. Mousa F.I.B.M.S pathology*(hamed@utq.edu.iq) Bassam A. Hassan, pharmacist MSc pharmacology** Abstract Background; Psoriasis is a one of the common dermatological diseases with no curative topical or systemic treatment, Curcumin is a naturally occurring phytochemical present in turmeric; it was traditionally used for the treatment of many skin diseases. This study was designed to evaluate the anti-psoriatic effect of curcumin preparations. Objectives; this study aimed to examine the probability of anti-psoriatic activity of topical curcumin by using mouse tail model. Methods; The extracted curcumin was assessed for antipsoriatic activity using a mouse tail model of psoriasis. 18 animals were divided into three groups (6 animals each). Group A: control group (cream base treated group) Group B: (treated with curcumin cream 1%) Group C: (treated with curcumin cream 2 %) Granular layer formation, epidermal thickness and drug activity were taken as an evaluating parameter to detect the efficacy of the new preparation. Results; The local application of curcumin 1%, 2% on the mouse tail skin produced a significant differentiation in the epidermis, as seen from its degree of orthokeratosis ( 43.4± 0.75) and ( 44.4 ±0.98 ) respectively when compared with the negative control (17.06±2.5 ). Conclusion;