Anti-Mullerian Hormone (AMH) and Age – An Indian laboratory retrospective analysis

Abstract

Introduction: Anti-Mullerian Hormone (AMH) is considered to be a sensitive biological indicator of the ovarian reserve among women. Produced by the granulosa cells in the ovary, AMH is also considered to be a good biochemical marker to time menopause, apart from being monitored during treatment of certain ovarian tumors. Our retrospective report is an attempt to study AMH levels across different age-groups between 18 – 50 years of age and present age-related changes in levels. Methods: Serum AMH estimation was done in a total of 219,227 Asian Indian women using the chemiluminescent immunoassay technology. Results: Our analysis of different age-groups with AMH levels detected a declining trend and a significant drop in levels was recorded between ages 19 – 20 years and 35 – 36 years of age at p<0.05. Conclusion: Our report is an attempt to present age-effect on AMH levels in a pan-India cohort of Asian Indian women and analysis detected a negative correlation between age and AMH levels.