PERFIL DE SENSIBILIDADE ANTIMICROBIANA DE CEPAS ESCHERICHIA COLI ISOLADAS DE INFECÇÕES URINÁRIAS COMUNITÁRIAS

Abstract

The urinary tract is one of the most common places of bacterial infection, and Escherichia coli is the main etiologic agent. In this study, 58 strains of Escherichia coli presented the following percentage of sensitivity to antimicrobial group A’: ampicillin 37.9%; cefazolin 56.1%; cephalotin 77.2%; gentamicin 96.6%; nitrofurantoin 85.7%; ofloxacin 94.6%. Results brought up that 94.8% of stumps are sensible to, at least, three antibiotics which had been tested in group A and neither of the isolated strains resistant to all the groups antimicrobials. The following results were found for antimicrobial group B’: amoxicillin/clavulamic acid 93%; ampicillin/sulbactam 100%; aztreonam 96.6%; cefepime 96.6%; cefoperazone 91.4%; cefotaxime 94.8%; cefoxitin 79.3%; ceftazidime 96.6% ceftriaxone 96.6% cefuroxime 94.6%; ciprofloxacin 93%; chloranfenicol 72.4%; tetracycline 53.4% and tobramicin 100%. In a preliminary screening, 18 (31%) samples were characterized as suspect of producing ESBL (extended-spectrum beta-lactamases), and the suspicion was confirmed by the additional test of beta-lactamase inhibitors in disks of betalactamic, in two stumps (3,5%). Our studies showed that the presence of Escherichia coli strains, isolated from urinary infections, producing ESBL in our environment is not a significant problem yet.. The sensitivity to the main antimicrobial groups was 98.3% to aminoglycosides, 93.8% to fluoroquinolones and 85.4% to beta-lactam antibiotics.