Human Induced Pluripotent Stem Cell–Derived Endothelial Cells for Modelling of Endothelial Dysfunction

Abstract

Human induced pluripotent stem cells (hiPSCs) cells are a type of cells derived from human somatic cells that are reprogrammed to an embryonic stem cell (ESC)–like pluripotent state. hiPSCs are being explored as disease modelling and drug discovery for diabetes mellitus. Modelling endothelial dysfunction using endothelail cells (ECs) derived from diabetic hiPSCs has the potential for evaluating the therapeutic effect of drugs or chemicals on endothelial dysfunction and for understanding the cross-talk between ECs and inflammatory cells or cytokines which will benefit the development of new therapeutic strategies for treatment of cardiovascular diseases. of