Saranyaraajan Varadarajan, Shahana A Chumki, Rachel E. Stephenson, Eileen Misterovich, Jessica L. Wu, Claire E Dudley, I. Erofeev, A. Goryachev, Ann L. Miller
{"title":"Mechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling","authors":"Saranyaraajan Varadarajan, Shahana A Chumki, Rachel E. Stephenson, Eileen Misterovich, Jessica L. Wu, Claire E Dudley, I. Erofeev, A. Goryachev, Ann L. Miller","doi":"10.1083/jcb.202105107","DOIUrl":null,"url":null,"abstract":"Varadarajan et al. find that calcium flashes regulate epithelial barrier function. Using live imaging, optogenetics, and laser-induced tight junction injury, they show that mechanosensitive channel-dependent calcium flashes promote sustained local activation of RhoA, allowing cells to repair tight junction leaks induced by mechanical stimuli.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"21","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1083/jcb.202105107","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 21
Abstract
Varadarajan et al. find that calcium flashes regulate epithelial barrier function. Using live imaging, optogenetics, and laser-induced tight junction injury, they show that mechanosensitive channel-dependent calcium flashes promote sustained local activation of RhoA, allowing cells to repair tight junction leaks induced by mechanical stimuli.
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