Research on the formulation rules of health food for improving sleep based on data mining

Abstract

Objective: To analyze the prescription rules of Chinese medicine health foods for improving sleep, and to provide references for the research and development of related health foods. Methods: Retrieve 581 types of sleep-improving Chinese medicine health food data approved before December 2020 from the official website of the State Administration of Market Supervision and Administration (SAMR), establish a health food database and conduct an overall analysis, including dosage form, function, frequency, etc., for raw materials The 109 formula, which is all Chinese herbal medicine, carries out frequency statistics, association rule analysis and visual analysis. Results: There were only 418 kinds of sleep improving effects, including 163 kinds of two or more effects. All of them were Chinese herbal medicines with high frequency of use, such as SEMEN ZIZIPHI SPINOSAE, PORIA and FRUCTUS SCHISANDRAE CHINENSIS. According to the efficacy classification, the top three traditional Chinese medicines with the highest frequency of use were Deficience-tonifying Drugs, Anxiety Drugs and Liver-soothing and Wind Resuscitating Drugs. The combination rule high-frequency drug pair includes RADIX SALVIAE MILTIORRHIZAE → SEMEN ZIZIPHI SPINOSAE; FRUCTUS SCHISANDRAE CHINENSIS, PORIA → SEMEN ZIZIPHI SPINOSAE; RADIX ET CAULIS ACANTHOPANACIS SENTICOSI → SEMEN ZIZIPHI SPINOSAE, etc.; The visualization results of association rule drug pairs show that the core compatibility is SEMEN ZIZIPHI SPINOSAE - PORIA - GINSENG - FRUCTUS SCHISANDRAE CHINENSIS - RHIZOMA GASTRODIAE. It is basically consistent with the principle of improving sleep in traditional Chinese medicine. Conclusion: Data mining and basic theoretical analysis of traditional Chinese medicine on the prescription rules of existing sleep-improving health foods can provide new ideas for the research and development of traditional Chinese medicine health products, so as to give full play to the advantages of traditional Chinese medicine and provide a basis for the public service of Chinese medicine health foods.