Characteristics of an ovine herpesvirus associated with pulmonary adenomatosis (jaagsiekte) in sheep.

E M de Villiers, H J Els, D W Verwoerd
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Abstract

The isolation of an ovine herpesvirus from a cell culture of an adenomatous sheep lung is reported, confirming previous observations of a possible association of a herpesvirus with this tumour. Some growth properties and morphological characteristics of the virus are described, as well as serological data supporting a possible relationship between tumour and virus. Attempts to produce jaagsiekte by intratracheal injection of virus into lambs were unsuccessful, suggesting that a second factor may be involved inthe oncogenic process possibly similar to that proposed for the well-known EBV-Burkitt's lymphoma system.

绵羊肺腺瘤病(jaagsiekte)相关羊疱疹病毒的特征
从腺瘤羊肺的细胞培养中分离出一种羊疱疹病毒,证实了先前关于疱疹病毒与该肿瘤可能存在关联的观察。描述了病毒的一些生长特性和形态特征,以及支持肿瘤和病毒之间可能关系的血清学数据。通过气管内注射病毒到羔羊体内产生jaagsiekte的尝试没有成功,这表明可能有第二个因素参与了致癌过程,可能类似于众所周知的EBV-Burkitt淋巴瘤系统。
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